Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer.

نویسندگان

  • Y J Guo
  • G Liu
  • X Wang
  • D Jin
  • M Wu
  • J Ma
  • M S Sy
چکیده

Soluble CD44 is present in the serum of normal individuals (2.7 +/- 1.1 nM). The concentration of soluble CD44 in the serum is elevated in patients with advanced gastric (24.2 +/- 9.8 nM) or colon cancer (30.8 +/- 11 nM). Serum CD44 concentration correlated with tumor metastasis and tumor burden. Surgical resection of tumors resulted in decreases in serum CD44 levels. By Western blot analysis, monoclonal anti-CD44 antibody reacted with a major protein with molecular weight between 130,000 and 190,000. In addition, two proteins with molecular weights of 72,000 and 80,000 can also be identified. Therefore, different CD44 isoforms may be present in the serum of cancer patients. Serum CD44 concentrations may be an indicator of tumor burden and metastasis in patients with malignant diseases.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Potential Use of Soluble CD44 in Serum as Indicator of Tumor Burden and Metastasis in Patients with Gastric or Colon Cancer

Soluble CD44 is present in the serum of normal individuals (2.7 +_ 1.1 riM). The concentration of soluble CD44 in the serum is elevated in patients with advanced gastric (24.2 + 9.8 riM) or colon cancer (30.8 411 riM). Serum CD44 concentration correlated with tumor metastasis and tumor burden. Surgical resection of tumors resulted in decreases in serum CD44 levels. By Western blot analysis, mon...

متن کامل

Potential Use of Soluble CD44 in Serum as Indicator of Tumor Burden and Metastasis in Patients with Gastric or Colon Cancer

Soluble CD44 is present in the serum of normal individuals (2.7 +_ 1.1 riM). The concentration of soluble CD44 in the serum is elevated in patients with advanced gastric (24.2 + 9.8 riM) or colon cancer (30.8 411 riM). Serum CD44 concentration correlated with tumor metastasis and tumor burden. Surgical resection of tumors resulted in decreases in serum CD44 levels. By Western blot analysis, mon...

متن کامل

Potential Use of Soluble CD44 in Serum as Indicator of Tumor Burden and Metastasis in Patients with Gastric or Colon Cancer

Soluble CD44 is present in the serum of normal individuals (2.7 +_ 1.1 riM). The concentration of soluble CD44 in the serum is elevated in patients with advanced gastric (24.2 + 9.8 riM) or colon cancer (30.8 411 riM). Serum CD44 concentration correlated with tumor metastasis and tumor burden. Surgical resection of tumors resulted in decreases in serum CD44 levels. By Western blot analysis, mon...

متن کامل

Evaluation of preoperative elevation of serum c-reactive protein as an indicator for prognosis of colorectal cancer

  Abstract   Background : Cancer has not been elucidated in colerectal site. C-reactive protein   (CRP) is a product synthesized in hepatocytes and has been reported to be up-regulated   by such proinflammatory cytokines as interleukin-1 (IL-1), interleukin-6 (IL-6),   and tumor necrosis factor (TNF). The significance of a preoperative serum elevation   was evaluated using CRP as a predictive i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Cancer research

دوره 54 2  شماره 

صفحات  -

تاریخ انتشار 1994